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KMID : 0366220050400010054
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Korean Journal of Hematology
2005 Volume.40 No. 1 p.54 ~ p.57
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A Case of Serum Amino Acid Disturbance with Hyperammonemia in Patient with Primary Amyloidosis
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Kim Yu-ri
Kim Jin-Seok
Park Sun-Young
Park In-Hae
Cheong June-Won
Lee Seung-Tae
Min Yoo-Hong
Hahn Jee-Sook
Kie Jeong-Hae
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Abstract
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There have been reports that hyperammonemia and amino acid disturbance can cause loss of consciousness in patients with multiple myelomas and normal liver function. We experienced a case of a 71-years-old female patient with amyloidosis, who had shown disturbance of consciousness. At that time, the serum ammonia level was elevated; serum amino acids disturbance was also noted. In particular, the decrease in branched-chain amino acids and increase in aromatic amino acids results in a low Fisher ratio. The Fisher ratio, the ratio of branched-chain to aromatic amino acids, has been suggested as an important indicator of consciousness disturbance. We report, for the first time in Korea, a case of amyloidosis, with mental disturbance due to serum amino acid disturbance.
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KEYWORD
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Amyloidosis, Amino Acid Disturbance, Hyperammonemia
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